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Overview of Osteoporosis, Weight loss and Endocrine (OWLE) Database

PI: Shapses SA

Department of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers, The State University, Department of Medicine (Division of Endocrinology, Metabolism and Nutrition), Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ; Director, NExT Center at the Institute of Food, Nutrition and Health. For inquires on this dataset, PI contact: shapses@rutgers.edu.

The OWLE data set comes from a continuous NIH grant (Nutritional regulation of bone from ongoing support-NIH-AG12161; total duration 1994-2016) to show how moderate weight loss affects bone, body composition or calcium absorption under various conditions in different cycles of this grant from the National Institutes of Aging (NIA).

Population and Study Design (OWLE)

  1. Healthy, Caucasian (85%), women (82%), and men (18%); ages 21-75 y and BMI 25-40 kg/m2
  2. All studies are diet intervention alone with similar nutrition education behavior modification intervention (ADA/AND Weight management)
  3. Duration of weight loss: 6-12 mo (~250 persons).
  4. Weekly nutrition/behavior counseling in the first 2 months, and twice monthly for 6 m studies, and once monthly for 1 year studies.
  5. Whole body composition (DXA) was performed before and after intervention.
  6. Serum and urine collected at baseline and multiple times during follow up (~3600 samples).
  7. Whole blood samples collected at baseline (~220 samples)
  8. True fractional Ca absorption in certain studies* (baseline and after Wt loss)
  9. 24-hour diet recall at baseline and food records were used to estimate nutrient intake during the intervention (~3 days/week – monthly).
  10. Micronutrient and food group data to assess diet quality.

Phenotypes and Biological Markers (OWLE)

  1. Body composition, bone mineral density and quality, rough estimate of physical activity & other lifestyle characteristics
  2. Height, weight, bloods (serum and whole blood), urine.

All subjects had physical, chem screen (glucose, etc.) and lipid levels at baseline.

For other related publications, see: ncbi.nlm.nih.gov/pubmed/?term=shapses+s

Details

  1. Shapses SA 2001 – Obese premenopausal women ages 21-45 y 3-arm study (2 levels of Ca with wt loss, WL, and wt stable) – 6 months
  2. Riedt CS, 2007* – Overweight -premenopausal – ages 21-45 y ; 3-arm study (2 levels of Ca with WL and wt stable) – 6 months
  3. Riedt CS, 2005* Overweight postmenopausal – 45-70 y 3-arm study (2 levels of Ca with WL and wt stable) – 6 months
  4. Sukumar D, 2011 Overweight/obese postmenopausal women ages 50-70 y (WL, 2 levels of protein) – 1 year
  5. Pop LC, 2015 – Overweight/obese older men, ages 50-72 y (WL and wt stable) – 6 mo intervention
  6. Shapses SA 2011*, Overweight/obese postmenopausal women ages 50-70 y (WL and 2 levels of vitamin D) – 6 week intervention
  7. Pop LC, 2017; Overweight/obese postmenopausal women ages 50-70 y; weight loss (3 levels of vit D) – 1 year
  8. Riedt CS, Obesity, 2006* (21 Roux Y gastric bypass surgery female patients)- before and 6 mo after surgery
  9. Goode LR, Obesity Res. 2004 (44 RYGB 3 yrs post-op and 65 age/weight matched controls; pre/post 6m after surgery subset with supple).